Laboratory of Cellular and Molecular Biology of Parasites
(Portugues)

Sergio Schenkman

Sergio Schenkman

Departament of Microbiology, Immunology and Parasitology

UNIFESP
Rua Botucatu 862 8 andar 04023-062 São Paulo SP BRASIL
Telefone: 55-11-55751996
FAX: 55-11-55715877
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 Research Interest 

Cellular and nuclear organization of Trypanosoma

Trypanosoma cruzi

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Our goal is to understand how the transcription, gene processing and differentiation process results in the cellular organization of Trypanosoma cruzi. These staudies aimed to understand the disease mechanism and to delineate the combact to Chagas' disease, which affect millions of people in Latin America. As an early eucaryote, our studies also provide tools to understand the origin of cell biological processes such as cell development, differentiation, aging and cancer. 

Biological role of Trypanosoma cruzi  trans-sialidase

Trypanosoma cruzi does not synthesize sialic acid but contains one enzyme that scanvange this carbohydrate from the hosts. This process, promoted by the trans-sialidase protects the parasite from the host immune response and provide a way to invade the mammalian cells, where it develops to produce the Chagas' disease.



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Team

Principal Investigator
Sergio Schenkman 

Research assistant and posdocs
Renata Tonelli 

PhD. students
Teresa Leandro de Jesus  
Sheila Cristina  Nardelli 
Alberto Cornejo 
Janete Chung
Bruno dos Santos Pascoalino

Master students
Thiago Cesar Prata Ramos 

Technicians
Claudio Rogerio de Oliveira
Claudeci Medeiros da Costa

Undergraduate students
Carolina Tsuchiya 
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